Mercury dental fillings a risk factor for cancer

Significant Mercury Deposits in Internal Organs Following the Removal of Dental Amalgam, & Development of Pre-Cancer on the Gingiva and the Sides of the Tongue and Their Represented Organs as a Result of Inadvertent Exposure to Strong Curing Light (Used to Solidify Synthetic Dental Filling Material) & Effective Treatment: A Clinical Case Report, along with Organ Representation Areas for Each Tooth

Abstract:

Because of the reduced effectiveness of antibiotics against bacteria (e.g. Chlamydia trachomatis, à-Streptococcus, Borrelia burgdorferi, etc.) and viruses (e.g. Herpes Family Viruses) in the presence of mercury, as well as the fact that the 1st author has found that mercury exists in cancer and pre-cancer cell nuclei, the presence of dental amalgam (which contains about 50% mercury) in the human mouth is considered to be a potential hazard for the individual's health. In order to solve this problem, 3 amalgam fillings were removed from the teeth of the subject of this case study. In order to fill the newly created empty spaces in the teeth where the amalgams had formerly existed, a synthetic dental-filling substance was introduced and to solidify the synthetic substance, curing light (wavelength range reportedly between 400-520 nm) was radiated onto the substance in order to accelerate the solidifying process by photo-polymerization reaction. In spite of considerable care not to inhale mercury vapor or swallow minute particles of dental amalgam during the process of removing it by drilling, mercury entered the body of the subject. Precautions such as the use of a rubber dam and strong air suction, as well as frequent water suctioning and washing of the mouth were insufficient. Significant deposits of mercury, previously non-existent, were found in the lungs, kidneys, endocrine organs, liver, and heart with abnormal low-voltage ECGs (similar to those recorded 1-3 weeks after I.V. injection of radioisotope Thallium-201 for Cardiac SPECT) in all the limb leads and V1 (but almost normal ECGs in the precordial leads V2-V6) the day after the procedures were performed. Enhanced mercury evaporation by increased temperature and microscopic amalgam particles created by drilling may have contributed to mercury entering the lungs and G.I. system and then the blood circulation, creating abnormal deposits of mercury in the organs named above. Such mercury contami nation may then contribute to intractable infections or pre-cancer. However, these mercury deposits, which commonly occur in such cases, were successfully eliminated by the oral intake of 100 mg tablet of Chinese parsley (Cilantro) 4 times a day (for average weight adults) with a number of drug-uptake enhancement methods developed by the 1st author, including different stimulation methods on the accurate organ representation areas of the hands (which have been mapped using the Bi-Digital O-Ring Test), without injections of chelating agents. Ingestion of Chinese parsley, accompanied by drug-uptake enhancement methods, was initiated before the amalgam removal procedure and continued for about 2 to 3 weeks afterwards, and ECGs became almost normal. During the use of strong bluish curing light to create a photo-polymerization reaction to solidify the synthetic filling material, the adjacent gingiva and the side of the tongue were inadvertently exposed. This exposure to the strong bluish light was found to produce pre-cancerous conditions in the gingiva, the exposed areas of the tongue, as well as in the corresponding organs represented on those areas of the tongue, and abnormally increased enzyme levels in the liver. These abnormalities were also successfully reversed by the oral intake of a mixture of EPA with DHA and Chinese parsley, augmented by one of the non-invasive drug-uptake enhancement methods previously described by the 1st author, repeated 4 times each day for 2 weeks.

Keywords: Dental amalgam, Mercury, Cardiac SPECT, Antibiotic resistance, Cancer, Pre-cancer, Leukoplakia, Abnormal liver enzyme, Chinese parsley (Cilantro), Drug-uptake enhancement, Organ representation areas, Bi-Digital O-Ring Test, EPA with DHA, Ultraviolet,Curing light, Gingiva, Tongue, Teeth, Oncogene C-fos Ab2, NO (Nitric oxide), ECGs, Chelating Agents, Radioisotope Thallium-201.

Introduction:

According to our previous study, the resistance to antibiotics of bacteria (frequently, Chlamydia trachomatis, Borrelia burgdorferi, à-Streptococcus), viruses (frequently, Herpes family viruses), and other microorganisms increases in the presence of localized deposits of mercury in the infected areas ( 1, 2, 4-7, 19). Furthermore, the 1st author found that the following diseases or situations are often associated with localized mercury and/or lead deposits in the pathological areas ( 2, 3, 19, 27-34, 37):

Pre-Cancer and Cancer (Every cancer and pre-cancer cell nucleus contains mercury while normal cell nuclei do not have mercury)

Essential Hypertension (The cardiovascular representation area on the scalp of the occipital area just above the medulla oblongata often has infection such as bacteria, virus, or Chlamydia, with localized deposits of mercury and/or lead)

Minamata Disease (coexistence of various infections, frequently Cytomegalovirus infection, and mercury or mercury compounds such as methyl mercury, which was originally discovered among people who regularly eat fish from the waters of Minamata Bay, Southern Japan, which has been mercury contaminated by industrial waste)
Amyotrophic Lateral Sclerosis (coexistence of viral infections, frequently Cytomegalovirus infection with Herpes Simplex Virus Type I or Type II, and mercury deposits)

Multiple Sclerosis

Alzheimer's Disease (often mixed viral and bacterial infections coexist with heavy metal in the hippocampus)
Parkinson's Disease (vital infection, most commonly Cytomegalovirus and Hg and/or Pb coexist in Caudate Nucleus, Substantia Nigra and often in Locus Cemleus and Red Nucleus)

Chronic intractable pain is often caused by Herpes Simplex Type 1 or Herpes Simplex Type 2 viral infections which coexist with Hg and/or Pb

Rheumatoid Arthritis (often occurring with Chlamydia trachomatis and/or Lyme Disease which coexist with Hg or Pb)
Psoriasis (viral infection and Hg often coexist in the involved area of the skin and subcutaneous tissue)
Following Cardiac SPECT Scan using intravenous injection of radioisotope Thallium-201 chloride for the evaluation of functional defects of the heart, the radioisotope Thallium-201 loses its radioactivity by electron capture mode and decays into mercury (atomic no. 80; average atomic weight 200.59; melting point: -38.8øC; boiling point: 357øC; density: 13.6 g/cm( 3) at 27øC) which is deposited mainly in all the endocrine organs, heart, liver, and kidneys.
(201)(81)TI + e(-) ---> (201)(80)Hg + Neutrino + X-ray (68-82KeV)

Please note: Mercury has 7 stable isotopes with identical atomic no. 80, one of which has an approximate atomic weight of 201, and naturally comprises 13.2% of all mercury. The other 6 known isotopes have approximate atomic weights of 202 (29.8%), 200 (23.1%), 199 (16.8%), 198 (10%), 204 (6.9%), and 196 (0.15%). There are 2 stable isotopes of thallium, with identical atomic no. 81, and they have approximate atomic weights of 203 (29.9%) and 205 (70.5%). The average weight of all thallium isotopes is 204.38 (melting point: 304øC; boiling point 1473øC; density: 11.83 g/cm( 3) at 270C). Radioactive thallium has 2 isotopes, with identical atomic no. 81. They are (20l)Tl (half-life: 73 hrs.) and (204)T1 (half-life: 3.77 yrs.).

12. Inhalation of excessive mercury vapor during unregulated extraction of gold from gold ore (involving the mixing of mercury with gold ore to create gold-containing amalgam, and then the forced evaporation of mercury by high temperature heating of the amalgam with flame torches, leaving behind a solid metal, comprised mostly of gold) by amateur gold miners occurs because the process is usually performed in the open air without any protective measures. In addition, non-professionals, who try to extract the gold from dental fittings using mercury often inhale excessive mercury vapor while heating the gold amalgams in small closed areas with poor air ventilation for a prolonged period of time, sicken, and then die from severe acute mercury intoxication.

Sources of mercury deposits in the human body include consuming fish, grains, or vegetables exposed to mercury contaminated water, eating foods cooked in pots coated with mercury to create a bright, shiny surface (which is the case with many brands of cookware with few exceptions, among them, stainless steel cooking pots made by Farberware) and served on some of the dishes, mugs and teacups decorated with colored glazes containing mercury or lead, exposure to mercury in the workplace, and silver/mercury amalgam fillings ( 16). Daily exposure to these sources of mercury can produce a significant health hazard when more than one source of mercury intake exists, and particularly when drinking a hot beverage from a cup coated with a glaze containing mercury. The 1st author's previous studies have found significant deposits of mercury localized in the pathological areas of people suffering from the first 10 conditions listed above ( 4-13, 16). Many of these people have silver/mercury dental fillings which are probably one of the sources of the mercury deposits since these fillings are a constant source and mercury is repeatedly released from them by chewing, grinding, eating acidic foods, and/or increasing the temperature of the amalgams by drinking hot soup, tea and coffee. Although the daily intake of mercury from the amalgam fillings may be insignificant compared with other sources, it can become a significant health hazard through its accumulation in the presence of bacterial and/or viral infections.
In this article, the effects of removing dental amalgam fillings and replacing them with a synthetic filling material not containing mercury, as the 1st author experienced the procedure early in 1996, is evaluated. In the process of removing amalgam by drilling, in spite of precautions against mercury ingestion and inhalation, following the removal of dental amalgam, significant mercury deposits were found in the lungs, all the endocrine organs, heart, liver, and kidneys non-invasively using the Bi-Digital O-Ring Test. However, these mercury deposits were subsequently successfully eliminated by the intake of Chinese parsley augmented by using various drug uptake enhancement methods previously developed by the 1st author. However, as an unexpected side effect of inadvertent exposure of the side of the tongue and gingiva next to the tooth to intensive curing light (wavelengths described to be between 400-520 nm) used to solidify the filling material by photo-polymerization, not only did the gingiva and the side of the tongue adjacent to the treated teeth become pre-cancerous, but the corresponding organs (including the liver) represented on those parts of the tongue also became pre-cancerous. One week after the completion of the dental procedure the subject experienced extreme fatigue and had his blood chemistry analyzed showing abnormally increased liver enzymes and other abnormalities. These conditions were reversed however by the use of the anti-viral agents EPA (Eicosa Pentaenoic Acid) and DHA (Docosa Hexaenoic Acid), and Chinese parsley with combinations of drug-uptake enhancement methods. The unexpected medical problems stemming from the dental procedure and their treatment, with suggestions for prevention, are presented in this article through the author's clinical experience as a patient.

Materials & Methods:

Subject's Relevant History:

During the past 20 years, a 62 year old male physician of Asian descent living in New York City has visited a number of dentists because of toothaches. He had paid little attention to the filling of his first 2 teeth more than 10 years ago but when a third filling was required a few years ago, he was shocked to learn that an amalgam of silver and mercury had been used. The 1st and 2nd authors had been invited to Minamata City in Japan by Dr. Sumio Arima, the editor of the well-known book, Minamata Disease (a 959 page book published in Japanese in 1979), to accompany one of the original researchers of that disease and evaluate patients with the Bi-Digital O-Ring Test. He was therefore aware of the coexistence of mercury and its organic compounds, such as methyl mercury, with infectious organisms, most commonly Cytomegalovirus, in the areas of the body affected by the disease.

The amalgam had been used to fill the cavities in 3 teeth: the lower left 4th (1st bicuspid) and 6th (1st molar), and the upper right 7th tooth (2nd molar). After the last amalgam was placed in the lower left 4th tooth a few years ago, the subject noticed frequent recurrent upper respiratory infections with marked increase of localized mercury deposits in the infected area, and developed pain in the upper left ann. The painful area in the upper arm was positive according to the Bi-Digital O-Ring Test for the coexistence of all 4 basic parameters for pre-cancer previously described ( 19, 27-34). Therefore, he decided to have all the amalgams (a total of 3) removed and replaced, and in March 1996, he went to a well established dentist to remove all 3 fillings. He was aware of the necessity of avoiding inhalation of mercury vapor or minute particles, or of swallowing mercury particles and discussed the need for precautions with the dentist. The dentist applied a strong air suction hood in front of the mouth and direct suction of saliva and water within the oral cavity, as well as frequent mouth washing during the drilling process on both visits. During the 1st visit, 2 amalgams were removed from the lower left 6th tooth and the upper right 7th tooth, and on the 2nd visit, the remaining amalgam was removed from the lower left 4th tooth. During the 2nd visit, the dentist also used a rubber dam around the teeth he was working on as a further precautionary measure. A synthetic filling substance, photo-polymerization type composite resin (Clean Fill AP-X) containing a significant amount of barium glass was placed into the dental cavities created by the removal of the amalgams in the lower left 4th and 6th teeth and the upper right 7th tooth. To solidify the substance, the dentist applied intensive curing light, which had a blue appearance, onto the synthetic filling substance for about 40 seconds each on the lower left 4th tooth, the lower left 6th tooth and the uppe r right 7th tooth.

A Simple, Non-Invasive Method for the Detection of Pre-Cancer or Cancer Using The Bi-Digital O-Ring Test:
The lst author has developed 2 unique methods for detecting the presence of cancer or pre-cancer. In the mid 1980's, he discovered the basic principles of the 1st method described below for detecting cancer cells, using microscopic slides of specific cancer cell types of specific internal organs as reference control substances to detect identical organ cancer cell types in the human body. By the late 1980's, the 1st author developed the 2nd method of pre-cancer screening, described below, using the Bi-Digital O-Ring Test. (Often, a combination of the 2 methods provides accurate and more specific information). These methods utilize the Bi-Digital O-Ring Test resonance phenomenon between two identical substances, which results in marked weakening of the Bi-Digital O-Ring ( 27-34):

Using an ultraviolet exposed microscope slide containing a specific type of cancer tissue of a specific internal organ as a reference control substance: If there is a strong Bi-Digital O-Ring Test resonance, characterized by marked weakening of the Bi-Digital O-Ring, one can state with very high probability that pre-cancer or cancer cells of that identical type exist in that specific internal organ. Diagnosis using this method requires many microscope slides of various cancer cell types of various internal organs. The microscope slides must be exposed to ultraviolet light (4 Watt battery operated portable ultraviolet light source for about 1 minute was used in most of our studies) to avoid the danger of false positive identification of pre-cancer or cancer cells caused by resonance between the bacteria or viruses which may incidentally coexist with the cancer tissue sample on the microscope slide, and the identical bacteria or virus also present in the patient, even if no cancer cells exist in the patient.

By detecting the coexistence of several characteristic findings for cancer tissue:
a) Integrin à( 5)á( 1) (marked increase)
b) Oncogenes (e.g. C-fos Ab2, C-ras, C-myc, etc.) (marked increase)
c) Hg (marked increase)
d) Acetylcholine = 0
e) [Viral infection]
f) [NO = 0]

The coexistence of the 1st 4 parameters in the 2nd method is essential to indicate pre-cancer or cancer. As long as a) b) c) & d) coexist, identification of vital infection is not necessary for screening of pre-cancer and cancer as it is always positive even in adenocarcinoma of the stomach in the presence of Helicobacter pylori. The viral infection in this study is indicated by the following conditions: 1) an extremely abnormal Bi-Digital O-Ring Test response (even the strongest Bi-Digital O-Ring can be opened by the examiner's weakest Bi-Digital O-Ring) found in the pre-cancer or cancer cells when tested without any reference control substance; and 2) when testing an adult patient with a mixture of EPA (180 mg) and DHA (120 mg) as a broad spectrum anti-viral agent, the response is no longer abnormal, and not only does the control Bi-Digital O-Ring remain closed, but also even the weakest Bi-Digital O-Ring, which normally opens, strengthens and remains closed; and 3) the specific viral infection is often identified by using a monochronal antibody of a specific virus as the reference control substance, and detecting strong Bi-Digital O-Ring Test resonance phenomenon between the monoclonal antibody and the corresponding virus. Cancer destructive effects of macrophage and NK cells are well known to be caused by the production and release of NO (Nitric Oxide or Nitrogen Mono-oxide) which is synthesized by the action of the NO synthesizing enzyme NOS on L-Arginine ( 53-59). Interferon-y released by inflamed cells also stimulate production of NO. Contrary to some reports ( 55) indicating that, in squamous cell carcinoma, inducible NO synthase activity is present and hints at the possibility that NO might be increased in cancer cells, NO could not be found in pre-cancer and cancer cells of various internal organs and therefore the absence of NO can be added to the list of co-existing parameters found in pre-cancer and cancer cells, even though it is found in normal tissue. However it is not essential to test for it as long as the first 4 parameters coexist.

In the above list of coexisting factors, b) lists various Oncogenes. The authors routinely use Oncogene C-fos Ab2, from the different oncogenes available, to screen for pre-cancer and cancer based on the observation that Oncogene C-fos Ab2 exists in every confirmed pre-cancer and cancer cell so far examined by him.

Non-invasive Estimation Of Mercury Deposits In Different Organs:

Non-invasive estimation of mercury deposits was performed using the Bi-Digital O-Ring Test resonance phenomenon between 2 identical substances. In this case, resonance phenomenon between mercury of a known amount as a reference control substance and mercury existing in different organs or tissues was evaluated by indirect Bi-Digital O-Ring Test. For the non-invasive evaluation of organic molecules in the blood chemistry, such as glucose, cholesterol, and uric acid, when performed properly, the amount estimated by the Bi-Digital O-Ring Test has an accuracy within ñ10% compared with direct standard blood chemistry laboratory tests. However, in the case of heavy metals like mercury, the amount of reference control substance required to produce maximum resonance is more than 10 times the amount found in biological tissue or fluid such as urine for a variety of reasons. With a known amount of mercury compound as a reference control substance the accuracy increases significantly. Therefore, at present, the Bi-Digital O-Ring Test is used quantitatively for the estimation of organic molecules such as glucose, Cholesterol and Uric acid, but unless specific organic compounds of mercury are used, the test can be used only semi-quantitatively for the estimation of mercury in biological systems ( 17, 18).

Safe And Effective Removal Of Mercury Deposited In Tissue:

Among the chelating agents commonly used for the removal of heavy metals like Hg (including methylmercury compounds) and Pb are CaEDTA (Calcium EtheleneDiamine Tetracetic Acid), combined BAL-CaEDTA, DMSA (meso-2, 3-Dimercaptocuccinic acid, or Succimer) and two monoesters of DMSA: Mi-ADMS (monoisoamyl meso-2,3 Dimercaptosuccinate), Mn-HDMS (mono-n-hexyl meso-2,3-dimercaptosuccinate), and DMPS ( 2, 3-Dimercaptopropane-1sulfonate) ( 48-52). However CaEDTA and BAL-CaEDTA must be given intramuscularly and often result in the formation of persistent and mildly disfiguring indurations with heavy metal at the site of the injections which may cause discomfort. Although DMSA has been commonly used recently, its derivative, Mn-HDMS has been found to be much more effective in removing heavy metals. The effect of DMPS is more effective than DMSA but less effective than Mi-ADMS and Mn-HDMS ( 48-52). Mi-ADMS and Mn-HDMS can be administered orally but their potential side-effects have not been well documented and prolonged use may cause the removal of essential metal ions such as Mg++.

In the spring of 1995, the 1st author found marked deposits of mercury in all the endocrine organs (particularly the thyroid gland, the testes and the pancreas), the heart, the liver, and the kidneys, following the intravenous injection of radioisotope Thallium-201 chloride for Cardiac SPECT (Single Photon Emission Computerized Tomography) Scan for evaluation of functional abnormality of the heart. Although he did not have any heart problems, he underwent the Cardiac SPECT Scan to obtain personal experience of the procedure as Director of Medical Research for the Heart Disease Research Foundation. Because of suspected contamination of the needle used to inject the radioisotope (by the nurse who was holding the needle coughing), he suffered from multiple infections following the procedure. After the infections were eliminated by detection of the the types of infections and optimal antibiotic treatment using the Bi-Digital O-Ring Test, he found the new problem of mercury deposits in the internal organs named above. These occurred when radioisotope Thallium-201 lost radioactivity, and changed to stable, nonradioactive mercury, which was deposited into certain internal organs. Although the physical half-life of the radioisotope Thallium-201 is 73 hrs., the biological half-life is often 3.5 times or longer, at which time the mercury deposits in the internal organs become very evident. About 2-3 weeks after the injection of the radioisotope Thallium-201 Chloride the 1st author noticed that he was losing unusually large amounts of hair every time he combed it, and that hair from his eyebrows and eyelashes was being left on the towel every time he dried his face after washing it. The ECGs taken at that time showed low voltage (maximum peak to peak voltage of QRS complex was about 0.5 mV) in all the limb leads and V1, while the chest leads V2-V6 were almost normal. The unusual hair loss stopped and the ECG's returned to almost normal after the mercury and radioisoto pe Thallium-201 deposits were eliminated from the body by the use of Chinese parsley with drug uptake enhancement methods. The remaining Thallium-201 was estimated by measuring the counts/minute of radiation with a Geiger counter held at the internal organs containing Hg deposits and at collected urine.

During the process of trying different methods of removing the mercury, one day after eating Vietnamese food for dinner, the 1st author noticed that the mercury deposits were markedly reduced in the internal organs according to the Bi-Digital O-Ring Test. The cause of this decrease in mercury was found to be Chinese parsley (Cilantro) an ingredient of the soup, which was, fortuitously, the only difference from the author's regular diet. In order to confirm whether Chinese parsley was really responsible for the marked decrease of mercury in the internal organs, before, during and after eating a fixed amount of the herb, urine was collected and examined, and found to have marked excretions of mercury, lead, and aluminum from about 2 hours after intake until 8 hours after the intake of Chinese parsley. Shortly after this finding, this experiment was repeated with more than 30 volunteers, and the 1st author found similar results ( 18). Since then, the method has been actively used to remove mercury successfully by the 1st author and many of his associates, and was again used as treatment for mercury removal in this clinical case study. It can also be used as an effective means of removing aluminum deposits after "Sand Blasting Method" using Aluminum Oxide powder in dentistry. The 1st author found that Chinese parsley also has anti-bacterial and anti-viral effects for many microbial infections as well as relatively strong anti-cancer effects, particularly when used together with a mixture of EPA and DHA, augmented by selective drug uptake enhancement methods to the pathological areas.

Use Of Drug-Uptake Enhancement Methods to Deliver Effective Drugs Selectively to the Pathological Areas When the Drug Alone Cannot Reach the Affected Areas at Therapeutic Levels:

To remove mercury, which was deposited in the internal organs as a side effect of removing amalgam fillings, the 1st author took a 100 mg tablet of Chinese parsley (specially prepared through the courtesy of Mr. Ken Hayashibara, President, & Dr. Shinobu Matsuda, Ph.D., Hayashibara Biochemical Laboratory, Okayama, Japan, at the request of the 1st author) 4 times a day for about 2 weeks. However, Thromboxane B( 2) is usually markedly increased in the areas of significant mercury deposits, indicating the presence of marked microcirculatory disturbance. The drug usually cannot reach therapeutic levels in the areas where there are significant mercury deposits and high levels of thromboxane B( 2). Therefore, the 1st author used 1 or 2 of many drug uptake enhancement methods previously reported in this journal to direct the medication selectively to the pathological areas containing mercury ( 20-26). The 1st author discovered several years ago that when the accurate organ representation areas on various parts of the body are stimulated by various methods listed below, there will be an improvement in microcirculation with marked decrease or disappearance of thromboxane B( 2), and significant selective drug uptake in the corresponding organ ( 20-26; 35-36). For this purpose, accurate organ representation areas, previously mapped using the Bi-Digital O-Ring Test, on the hands, feet, tongue, or ears can be used, but accurate organ representation areas of the hands are used most frequently since the organ representation areas are easily located, and the patients can easily stimulate the locations themselves with proper instruction. The following are among the effective means of stimulating the organ representation areas ( 20-26):

Shiatsu massage

Acupuncture
Heat including moxibustion
(+) Qi Gong or (+) Qi Gong energy stored paper
(-) Electrical field from DC batteries
South pole of magnetic field
White light from tungsten DC powered flashlights

White light from krypton DC powered flashlights (more effective than tungsten)
Krypton flashlight beam with specific type of red cellophane coverings used as a filter
Red spectrum or spectra, without spectral component shorter than green light
Near infrared light from a solid state Laser Diode
Extremely low pulse repetition rate electrical pulse stimulation

(Medicines which improve circulation and enhance drug uptake include Chinese herb medicines known to improve circulatory disturbances and some Calcium channel blockers.)

Among these methods, the most commonly used are Shiatsu, (+) Qi Gong energy stored paper, small hand-held 3V D.C. battery-powered krypton flashlight with red cellophane used as a filter, and (-) electrical field, all of which are safe and non-invasive.

Results and Discussion:

During the past 20 years, a now 62 year old male physician went to a number of dentists for treatment of dental caries. Amalgams composed of about 50% Hg, 35% Ag, 9% Sn and 6% Cu were used to fill the cavities in 3 teeth, the lower left 4th and 6th teeth, and the upper right 7th tooth. After the last amalgam was placed into the lower left 4th tooth, he experienced frequent recurrent upper respiratory infections with marked increase of localized deposits of mercury in the infected area, and developed pain in the upper left arm. The painful area in the upper arm, according to the Bi-Digital O-Ring Test, satisfied all the criteria for pre-cancer ( 27-34). Since one of the parameters is the presence of Hg, he decided to have all the amalgams (a total of 3) removed from his teeth, and went to a dentist with a good professional reputation. Precautions were taken to avoid any excessive inhalation of mercury vapor or minute amalgam particles or powder, or th e swallowing of small amalgam particles. The dentist applied strong air suction in front of the mouth and direct suction of saliva and water, used to cool and wash the drilled areas. There was also frequent mouth washing during the drilling procedure.

A synthetic filling material was used to fill the dental cavities created by the removal of the amalgams in the lower left 4th and 6th teeth, and the upper right 7th tooth, and in order to accelerate solidification of this filling material, the dentist applied an intensive bluish curing light beam, which also contained much shorter wavelengths including ultraviolet light, for about 40 seconds onto the lower left 4th tooth, the lower left 6th tooth and the upper right 7th tooth. The authors were able to observe the entire procedure through the use of a mirror during both procedures. While the curing light was used, he noticed that the sides of the tongue adjacent to the teeth were inadvertently, but continuously exposed to the intensive curing light for most of the approximately 40 second period of exposure for each tooth. At the time, the 1st author contemplated the potential side-effects of the exposure of the organ representation areas on the sides of the tongue to the intensive curing light, particularly if the intensive curing light contained ultraviolet rays that may cause pre-cancerous conditions, but soon forgot about these suspicions after the procedure.

Approximately 1 day after the 1st visit (in which 2 of the 3 dental amalgams were removed), the Bi-Digital O-Ring Test showed markedly increased deposits of mercury in the lungs, liver, kidneys, heart, and all the endocrine organs although before the procedure of removing amalgams there were no significant deposits of mercury in these organs. To remove the mercury deposits in various organs, an optimal dose of 100 mg of Chinese parsley, determined by the Bi-Digital O-Ring Test, was taken 4 times a day with 1 cup of water each time, immediately after detection of the mercury deposits. Each time Chinese sparsely was taken, a combination of drug uptake enhancement methods, specifically Shiatsu, was applied to the organ representation areas on both hands corresponding to the lungs, heart, liver, kidneys, and all the endocrine organs (see Figure 1 below). Within 10 days of Chinese parsley treatment, most of the mercury deposits were excreted with the exception of a mild presence of mercury in the thyroid gland, and an even slighter presence of mercury in the other endocrine organs, including the pancreas.

The remaining amalgam was then removed on the 2nd visit. The dental cavity created by the removal of the amalgam was filled with a synthetic filling material known as Photo Polymerization Type Composite Resin Clear Fill AP-X. The solidification of the synthetic filling material was again accelerated with an intensive blue curing light applied for about 40 seconds onto the lower left 4th tooth. One day after the dental procedure, marked mercury deposits were again detected in the lungs, heart, liver, the kidneys, and all the endocrine organs, especially the pancreas and the thyroid gland with moderate low voltage of R-waves in all limb leads and chest lead V1 ECGs. To remove the mercury, the 1st author used Chinese parsley, beginning the day before having the last remaining amalgam in the left lower 4th tooth removed, and drug uptake enhancement methods with Shiatsu on the corresponding organ representation areas on the hands, but this time, in addition to Shiatsu, he also used white light from a krypton bulb powered by 3 volt DC battery and covered with red cellophane as a filter, to further strengthen the drug uptake enhancement effect. When most of the mercury was excreted, low voltage ECGs also returned to almost normal.

Some of the factory produced krypton light flashlights purchased by the 1st author and his associates in the past had a certain plastic flashlight flat lens instead of glass. Certain synthetic materials that markedly weaken the Bi-Digital O-Ring Test response always inhibit drug uptake. Red filters made of synthetic materials such as polyester inhibit drug uptake as well. Red light from a laser diode with a wavelength of 670 nm or longer usually enhances drug uptake. However, red light from light emitting diodes that, in addition to the red spectra longer than 610 nm, contain wavelength components shorter than about 500 nm often inhibit drug uptake. Even if the red light from a light emitting diode does not have a wavelength shorter than 500 nm, if the red light is emitted from a light emitting diode (LED) encapsulated with certain synthetic materials that markedly weaken the Bi-Digital O-Ring Test response, it will inhibit drug uptake as in many red color LEDs. But in general, krypton light flashlights from Radio Shack produce a significant drug uptake enhancement when the organ representation areas are exposed to the light for about 1 minute, while xenon or halogen lamps inhibit drug uptake.

In this study, the 1st author exposed the organ representation areas on the hands to the red light from a Radio Shack krypton flashlight with red cellophane used as a filter for drug uptake enhancement. Each part of the hand was exposed for a minimum of about 1 to 2 minutes each time after Chinese parsley was taken. With repetition of this procedure more than 4 times each day, most of the mercury was excreted within 1 week with the exception of slight remaining mercury deposits in the liver, kidneys, pancreas, thyroid gland, and to a lesser extent, in other endocrine organs. Along with a mild abnormal condition in the thyroid gland, the Bi-Digital O-Ring Test also indicated the presence of very abnormal conditions in the liver and pancreas and moderate abnormality in the kidneys. During this time, the 1st author also suffered from moderate fatigue, dry mouth in the early morning, and moderately increased frequency of urination which could be the effect of taking Chinese parsley, which seems to have diuretic effects particularly when taken with a cupful of water to reduce excessive concentration of mercury in the kidneys, the urinary bladder, and in the urine. At this point, 1 week after the remaining 3rd amalgam was removed, the blood chemistry was examined. The blood chemistry & CBC results are shown in Table 2

The only abnormality found in previous blood tests was slightly elevated total cholesterol, with all other parameters normal. At the time the blood test was performed, in March, 1996, the authors were puzzled about the possible cause of the abnormalities found in the blood chemistry above. The following is a discussion concerning the possible causes of the abnormal blood chemistry and CBC findings. Serum mercury measurement was ordered, but unfortunately not carried out as it required a separate request form.

The slight abnormal increase in á Globulin of 11.4% (normal upper limit: 11.3%) in the blood chemistry may be associated with abnormally increased blood glucose level of 140 mg/dl, which may be an indication of mild diabetes or pre-diabetes.

There was a moderate abnormal increase in the GPT (Glutamic Pyruvic Transaminase) level at 42 units (normal upper limit: 35 units). GPT normally exists in the liver, kidneys, heart muscle, and skeletal muscle. An increase in GPT is most significant when there is a denaturing or necrosis of liver cells such as in the case of acute hepatitis. A mild increase in GPT is characteristic of chronic hepatitis, alcoholic hepatitis, fatty liver, liver cirrhosis, or liver cancer.
The ç - GTP (ç - Glutamyl Transpeptidase) level at 105 mu/ml was twice as high as the normal upper limit (50 mu/ml). ç - GTP is an enzyme that exists mainly in the epithelial cells of the liver, kidneys, and pancreas. It is required to decompose ç - glutamylpeptide and to transfer the ç - glutamyl radical to another peptide or amino acid. It increases in level during an occlusive liver or gall bladder system disease. In addition, ç - GTP levels often increase in chronic hepatitis, liver sclerosis, liver cancer, alcohol liver damage, drug-induced liver damage, bile duct system disease, cancer in the head of the liver, and myocardial infarction. Since the 1st author rarely drinks alcohol, alcohol related problems may be excluded. However, ç - GTP levels mainly increase in cases of liver and gall bladder disease, and therefore, it is often used to screen for cases of liver and gall bladder disease.

The blood chemistry also showed mildly increased total cholesterol at 259 mg/dl (normal upper limit: 220 mg/dl). Triglycerides increased slightly at 171 mg/dl (normal upper limit: 160 mg/dl).

There was a slight increase in BUN (Blood Urea Nitrogen) at 20.4 mg/dl (normal upper limit: 20 mg/dl). Urea is the final product of protein metabolism. It is synthesized in the liver from CO( 2) and ammonia generated from amino acids. Urea is normally excreted into the urine after filtration of the blood in the glomerulus in the kidneys, therefore, measurement of blood concentration of urea nitrogen is widely used to assess kidney function. It increases in cases of kidney dysfunction, kidney failure, urinary tract occlusion, dehydration, excessive intestinal hemorrhage, starvation, or excessive protein intake. However, BUN is not a particularly sensitive measure of kidney function similar to creatinine. BUN levels begin to increase from normal range only when the glomerular filtration rate is reduced 30% from the normal rate. Therefore, even a slight increase in BUN may be an indication of a moderately decreased glomerular filtration rate.
There was a mild increase in uric acid at 7.8 mg/dl (normal upper limit for males: 6.3 mg/dl) in the blood chemistry. Uric acid, the major end metabolite of purine, a major component of nucleic acid, in the blood is measured to confirm diagnosis for gout, and to detect kidney dysfunction. It is secreted from the glomerulus, but most is reabsorbed through renal tubules. Therefore, increased levels of uric acid may be due to excessive production of uric acid or decreased secretion from the kidneys. Increased blood levels of uric acid may indicate gout, Lesch-Nyhan Syndrome, leukemia, chronic impaired renal function, malignant tumors, acidosis, inhibition of uric acid secretion by various drugs, congestive heart failure, Von Gierke's Disease, infections, hemolytic anemia, sickle cell anemia, polycythemia, or psoriasis.
The blood chemistry results revealed a slight increase in TSH (Thyroid-Stimulating Hormone) at 4.27 æU/ml (normal upper limit: 3.20 æU/ml). TSH, a large glycoprotein (m.w. = 28300), is secreted from the anterior pituitary gland after stimulation by TRH (Thyrotopin-Releasing Hormone). TSH combines with TSH receptors on the epithelial cells of the thyroid, and stimulates an increase in the size, number, and secretory activity of thyroid cells, enhances iodine pump activity with the help of cyclic AMP, promotes the release of triiodothyronine (T3) and Tetraiodothyronine (Thyroxine,T4), and stimulates synthesis of thyroglobulin. These TSH induced processes and negative feedback of the thyroid hormones are controlled by TRH released from the hypothalamus to stimulate release of TSH from the anterior pituitary gland. Therefore, the measurement of TSH is used for differential diagnosis of primary and secondary thyroid hypofunction syndrome, and is useful for the evaluation of the therapeutic effect of primary thyroid hypofunction syndrome or primary thyroid hyperfunction syndrome treatment. Significantly increased levels of TSH may indicate primary thyroid hypofunction syndrome, endemic goiter, or surgical removal of the thyroid, TSH producing tumor, and Thyroid hormone non-response syndrome, while slightly increased levels appear in euthyroid patients with thyroid cancer.

Lastly, there were abnormal levels of leukocytes in the white blood cell differential, specifically a slight increase in segmented neutrophil at 57% (normal upper limit: 55%), a slight decrease in stab neutrophil at 2% (normal lower limit: 3%), and no detectable trace of eosinophil at 0% (normal lower limit: 1%). White blood cell differentials are taken to assess the body's ability to overcome infection, particularly bacterial infection, to determine the stage and severity of an infection, as well as to detect allergic reactions and various types of leukemia. Neutrophils, in general, increase with intoxications by digitalis mercury, lead, or chloroform, as well as bacterial infections, ischemic necrosis due to myocardial infarct, burns, malignant tumors, metabolic disorders such as diabetes, stress response due to physical or emotional trauma, inflammatory disease such as rheumatoid arthritis, acute gout, renal disease, endocrine disease such as Cushing's syndrome, and an increase in steroid hormones. A decrease in neutrophil levels, however, suggests bone marrow depression due to radiation or cytotoxic drugs, severe infections, hypersplenism, or collagen vascular disease. Eosinopenia (when eosinophils comprise less than 2% of all leukocytes) appears in stress responses to trauma, shock, surgery, or mental distress, to endocrine diseases such as Cushing's syndrome, blood diseases such as malignant anemia, aplastic anemia, granulocytopenia, early stage of various infections with the exception of Scarlet fever and measles.

The increase in TSH level suggested some abnormality in the thyroid gland. The abnormal liver enzyme levels also suggested some abnormality in the liver, and the increased glucose level suggested some abnormality in the pancreas. The results from the blood tests seemed to correspond to the moderate amount of mercury remaining in the thyroid gland, and to the very abnormal conditions in the liver and the pancreas detected by the Bi-Digital O-Ring Test before the blood chemistry was taken. Our previous research has indicated that when there is a Chlamydia trachomatis infection, uric acid is markedly increased in the infected areas, creating pain often classified as gout pain. The increase of uric acid in the infected areas is often accompanied by an increase in blood levels of uric acid that is more commonly associated with excessive intake of animal meat. In spite of the high sensitivity of the Bi-Digital O-Ring Test, however, Chlamydia trachomatis was not detected anywhere in the patient's body, probably because the 1st author eats meat infrequently. Therefore, the slight increase in blood Uric acid and urea nitrogen may suggest some kidney dysfunction.
About 2 months after the second dental procedure, the 1st author noticed increased general malaise, moderately increased frequency of urination, and frequent occurrences of fatigue, which reached maximum severity at around 3 and a half months after the dental procedure. At the time, even the smell of detergent caused nausea. Therefore, in order to estimate the presence of any abnormality in the body, the tongue was first examined in the mirror, since the 1 st author had mapped the accurate organ representation areas of most of the internal organs on the tongue several years ago using the Bi-Digital O-Ring Test. Accumulated clinical experience indicates that using the accurate organ representation areas on the tongue, one can often make far more accurate diagnoses of conditions of internal organs than by using the traditional Chinese tongue diagnostic method ( 35-38). The 1st author found purple discolorations on areas of the tongue that approximately corresponded to the areas adjacent to the teeth from which the amalgams were removed and on which the intensive bluish curing light had been exposed. In addition, areas of gingiva around the lower left 6th tooth showed erythema at the root of the tooth with Leukoplakia below and surrounding the erythema, which are often indications of pre-cancer ( 44-47). Since the discolored areas on the side of the tongue corresponded approximately to the areas exposed to the intensive bluish curing light beams used on the lower left 4th tooth and, the lower left 6th tooth, the 1st author decided to examine these areas for the possible presence of a pre-cancerous response according to the Bi-Digital O-Ring Test.

As described in the Materials & Methods section, by the late 1980's the 1st author had already discovered the following 2 methods of pre-cancer screening using the Bi-Digital O-Ring Test: (often, a combination of the 2 methods provides more accurate and specific information than either method alone) ( 27-34)

Using ultraviolet exposed specific-type of cancer tissue of a specific internal organ in microscope slides as reference control substance.

By detecting the coexistence of several characteristic parameters which indicate the presence of pre-cancer or cancer tissue:
a) Integrin à( 5)á( 1) (marked increase)
b) Oncogene C-fos Ab2 (marked increase)
c) Hg (marked increase)
d) Acetylcholine = 0
e) [Viral infection]
f) [NO = 0]

All of the 6 parameters of the second method which coexist in pre-cancer and cancer showed a strong positive response in the intensive curing light exposed areas of the tongue adjacent to the lower left 4th tooth and the lower left 6th tooth and erythema surrounded by leukoplakia developed on the gingiva directly below the lower left 6th tooth. The next areas examined were the organs which corresponded to the areas of the tongue that were discolored, to see whether there were any abnormalities such as pre-cancer in the corresponding internal organs represented on the parts of the tongue exposed to the intensive bluish curing light. Since the 1st author had previously mapped all the organ representation areas on the surface, sides, and underside of the tongue, the corresponding organs on the side of the tongue next to the lower left 4th tooth were found to be the liver, the lateral part of the leg just above the knee, and the 5th fingers of both hands ( 35, 36). (see Figure 2 & Figure 3).

Therefore, the whole body was directly examined for areas that were positive for the 6 coexisting parameters of pre-cancer or cancer. Strongly positive areas included both sides of the tongue, the entire liver, the lateral side of the area above the knee, and the 5th fingers of both hands.When the pre-cancer areas were detected, the 1st author, based on many previous volunteer subjects with pre-cancer and 6 volunteer subjects with cancers whom he had treated with successful results including disappearance of most signs of pre-cancer and cancer ( 2, 4, 19), decided to use the same treatment personally. He took capsules containing a mixture of EPA with DHA, and Chinese parsley tablets augmented by the use of drug uptake enhancement methods. The treatment consisted of a mixture of EPA (180 mg) and DHA (120 mg) as anti-viral agents for the viral infections involved in the pre-cancer or cancer, and Chinese parsley (100 mg) 4 times a day to remove mercury present in the nuclei of pre-cancer or cancer cells, with selective drug uptake enhancement methods, specifically stimulation of the organ representation areas of the hands with strong Shiatsu massage ( 25).

However, unlike any previous case, there was no decrease in any of the parameters at all in the 1st author. It was found that the drugs reached the pre-cancer or cancer areas immediately after completing drug uptake enhancement stimulation, but 10 - 20 minutes later, no drug was found to be present in the pre-cancer positive areas described above despite drug uptake enhancement stimulation and initial drug uptake increase. Further study based on previous findings made in 1995 with volunteer subjects revealed close contact of the body with certain of the following items to cause the inhibition of drug uptake into the pre-cancer or cancer areas that was detected 10 - 20 minutes after strong drug uptake enhancement stimulation:

Eyeglasses
Undershirt
Shorts
Socks
Night clothes
Bed-sheets
Clothing labels
Wristwatch and its band
Jewelry (necklaces, bracelets, rings, and earrings, made of metal)
Brassieres, especially with metal wires, and pads

Shoulder pads

Shoe liners and linings

The 1st author found that any material in close contact with the body surface that showed Bi-Digital O-Ring weakening response resulted in drug uptake inhibiting effects not only in the vicinity of the area of contact, but sometimes, in a much broader area. For example, wearing eyeglasses inhibits drug uptake in a certain area in the GI tract, as well as in the lower extremities below a line about 10 cm above the knee joint. The 1st author found that most synthetic materials like polyester inhibit drug-uptake, while 100% cotton without any dyes or artificial whitening was found not to cause drug uptake inhibition. However, 100% cotton that is dyed with certain coloring agents will inhibit drug-uptake. Though 100% cotton materials do not usually inhibit drug-uptake, the clothing labels attached to the cotton clothing are commonly made of materials that inhibit drug-uptake.

After removing all materials that inhibited drug-uptake, the treatment resulted in the rapid disappearance, within 2 weeks, of the parameters that coexist in pre-cancer and cancer. Blood chemistry was tested immediately after the disappearance of the coexisting pre-cancer and cancer parameters. All the previous abnormalities in the blood chemistry had disappeared after the pre-cancer treatment of EPA with DHA and Chinese parsley with drug uptake enhancement methods (see blood chemistry results after treatment). The pre-cancerous areas of the liver, the lateral side of the knee and the 5th fingers no longer gave positive responses to the 5 parameters which, when coexisting, indicate pre-cancer or cancer, with significant improvements in all previous symptoms described. Treatment was continued for an additional 10 days after the disappearance of the parameters.

According to the author's research, each tooth corresponds to slightly different combinations of internal organs. The last amalgam was removed from the 4th tooth on the left side of the mandible. According to our study, all 4th teeth on both sides of the mandible and maxilla correspond to the small intestine, lung, colon, liver, stomach, pancreas, spleen, urinary bladder, prostrate gland and testes (in males), ovary and uterus (in females), adrenal gland, and parathyroid gland. The 6th teeth on both sides of the upper and lower mandibles correspond to the small intestine, lung, colon, liver, stomach, pancreas, spleen, urinary bladder, prostate gland and testes (in males), ovary and uterus (in females), adrenal gland, thyroid gland and parathyroid gland. Strong stimulation of these teeth may influence the conditions of these organs. The 7th teeth on both sides of the upper and lower mandibles correspond to the small intestine, lung, colon, liver, stomach, pancreas, spleen, urinary bladder, prostate gland, testes, ovary, uterus, adrenal gland, and para-thyroid. The detail of the corresponding internal organ for each tooth is summarized in the schematic diagrams shown in Figures 4A and 4B.

In addition, each tooth represents a specific anatomical region of the body in a systematic manner, including representation of the skeletal bones and the body's mechanical supporting structures covering the outside of the body such as the chest or abdominal walls, as shown in Figure 5. For example, the head and face are represented on the medial half of each 1st tooth (the central incisor), cervical vertebrae and the upper extremities are represented on the lateral halves of the incisors in that order. Specifically, the upper extremity is represented by the lateral area farthest away from the center of the maxilla or mandible on the 1st tooth, with the hand represented by an area in this lateral region near the gum line, and the upper arm represented at the outer tip of this lateral region. The upper extremity representation area on the 1st tooth also corresponds to the 6th and 7th cervical vertebrae. The 2nd tooth (lateral incisor) contains the representation for thoracic 1st - 6th vertebrae. The 3rd tooth (incisor, or cuspid) represents thoracic 7th vertebra to the end of the sacrum-coccyx bone. The extreme lateral side away from the center of the mandible of the 4th tooth (lst bicuspid), about 1/6-1/7th of the width of the entire tooth, represents the lower extremity. The area near the gum line on this extreme lateral side represents the toes and foot, while the center area at the lateral side of the 4th tooth corresponds to the knee, and the lateral tip corresponds to the thigh. The lower half of the 4th tooth near the gum line, with the exception of the extreme lateral side that represents the lower extremity, represents the dorsal thoracic ribs corresponding to the area of thoracic vertebra 1 to the end of the sacrum-coccyx bone. The top half of the 4th tooth, with the exception of the extreme lateral side representing the lower extremity, corresponds to the pelvis, including the pelvic bones of the hip. The 5th tooth (2nd bicuspid) represents the ch est (mainly the front wall of the chest) as well as the organs nearest to the chest wall such as the lungs or the breasts. But as can be seen from Figures 4A and 4B, all the 5th teeth do not represent the heart. However, the heart is represented only in the 1st, 2nd, 3rd, and 8th teeth, but the 8th tooth is the only one that has the small intestine representation as the "Paired Organ" in traditional Chinese medicine. According to the Figures 4A and 4B, the lungs, the colon, the testes, the prostate glands and the ovaries are represented in all teeth, therefore a problem of multiple teeth may represent disease of some of these internal organs. Recently the 1st author has seen 2 patients who developed problems in the 5th teeth which coincided with early stages of rapidly developing lung cancer. The 6th tooth (1st molar) represents the upper abdomen and organs within it. The 7th tooth (2nd molar) represents the lower abdomen and its organs. Lastly, the 8th tooth (3rd molar or wisdom tooth), represents the side of the chest on the medial half nearest to the center of the maxilla or mandible, and the side of the abdomen on the lateral half (See Figure 5). If the teeth are extracted the organ representation areas remain within the tooth sockets. The various relationships between the normal and abnormal teeth and the normal and abnormal conditions of their corresponding parts of the body are now being investigated by the authors.

In this case study, the most obvious and distinctive findings indicating a possible relationship between certain dental procedures and medical problems are:

Intensive bluish curing light beam exposure on the side of the tongue adjacent to the lower left 6th tooth appeared to be the major cause of discolorations in that area

Pr-cancerous conditions were detected in these intensive bluish curing light beam exposed areas on the sides of the tongue as well as in the corresponding organs represented, specifically in this case, the liver, the lateral part of the thigh just above the knee, and the 5th fingers of both hands

Erythematous swelling surrounded by Leukoplakia appeared at the gingiva surrounding the left lower 6th tooth which was exposed to intensive bluish curing light

Sudden appearance of abnormal blood chemistry indicating mild dysfunction of the liver, pancreas, thyroid gland, and kidneys, after the excretion of most of the Hg deposits resulting from the removal of the dental amalgams
Those discolored pans of the tongue which were exposed to the intensive bluish curing light corresponded to the liver (but not the entire organ), the lateral side of the thigh above the knee, and the 5th finger. However, the entire liver and the hands and thighs developed abnormal conditions, showing a positive response for all 6 parameters for pre-cancer or cancer, and abnormalities appeared symmetrically on both sides of the tongue, though the right side was not exposed to the strong curing light. The right side of the tongue, however, showed less significant changes than the left, more exposed side of the tongue. The maximal exposed distance corresponding to the liver representation area could not be more than 1.2 - 1.5 cm in length at each abnormal area.

Concerning the visibly discolored regions, certain areas were exposed more frequently than others, specifically organ representation areas of parts of the liver that constituted a darkly purple-reddish discolored semi circular area with a maximum length along the edge of the tongue of about 1 cm and a maximum width of 6 mm starting at the edge of the tongue and extending towards its center. About 3 mm of a halo-like lighter purple discolored area surrounded the previously described deeply discolored semi-circular area closest to the lower left 4th tooth and the lower left 6th tooth. This entire discolored region tested strongly positive to the 6 coexisting parameters of pre-cancer or cancer, but after 2 weeks of treatment, this region was no longer discolored. There was also a complete disappearance of the 6 coexisting parameters of pre-cancer or cancer, a normalization of the corresponding organs and blood chemistry, and a disappearance of the symptoms. The last 2 of the 6 co-existing parameters to normalize were the reappearance of Acetylcholine and NO.

This study, although limited to a single clinical case, clearly indicates that removal of amalgam fillings, regardless of how meticulously done, can be a health hazard because evaporation of the mercury from the dental amalgam to mercury vapor by the heat of the drilling, and minute particles of amalgam pulverized by the drill enter the lungs and G.I. system and eventually the heart, liver, kidneys and endocrine organs, including the pancreas, and these deposits of mercury can increase bacterial, viral, and other microbial resistance against antibiotics ( 1, 2, 4-7, 19). Mercury from amalgam fillings can also enter the body through an electrochemical process stemming from the difference in electrical potentials existing between 2 dissimilar metals used on the different teeth in the oral cavity.

Presence of heavy metal deposits inside the body creates additional hazards since they function as multiple microscopic antennae for electromagnetic fields that exist in the environment. When the individual is repeatedly exposed to strong electromagnetic fields, tissue adjacent to the mercury deposits is vulnerable to enhanced effects of electromagnetic fields and/or damage that would not occur in the absence of mercury. The author's previous study indicated that exposure to electro-magnetic fields with relatively low frequency (less than about 50 kHz) induces: 1) increase in Oncogene C-fos Ab2, 2) decrease in Acetylcholine, 3) decrease in NO, 4) increase in thromboxane B2 (which indicates circulatory disturbance). When the frequency of the electromagnetic field is much higher than about 100 kHz additional Integrin à( 5)á( 1) began to appear and the higher the frequency the higher the amount of the appearance of Integrin à( 5)á( 1) at the exposed part of the body, (for example, when the body is exposed, within 5 cm, to the electromagnetic field of a cellular phone in broadcasting mode, which has a frequency of about 0.5 GHz - 0.9 GHz [often between 824.030-848.098 MHz in USA], or exposure to within 2 or 3 m of microwave radiation leaking from a microwave oven, which has a frequency of 2.45 GHz) These findings have been described in detail by the authors ( 40-43). Therefore, local deposits of mercury plus repeated electromagnetic field exposure, particularly those with extremely high frequency can provide all the necessary parameters required for the presence of pre-cancer or cancer. The effects of such concentrated absorption of electromagnetic fields by tissue containing heavy metals such as mercury can contribute to the genesis of pre-cancer and cancer of specific organs of the body ( 40-43).

According to other researchers ( 5-7), mercury vapor exposure from dental amalgams can enrich mercury-resistant plasmids in normal bacterial flora in non-medicated primates. Many of these plasmids also carry antibiotic resistance, some of which appear to be genetically linked with mercury resistance, so that mercury and other antibiotic resistance are often transferred together. Therefore, the exposure of mercury vapor from dental amalgams may be linked to an increased incidence of multiple antibiotic resistant plasmids in the normal bacterial floras of non-medicated subjects ( 5-7). Although there is a consensus that mercury itself is toxic, there is still debate about the possible health hazard of mercury in dental amalgams. While many studies implicate mercury in dental amalgam as a health hazard, others report contrary results ( 14-16).

The problems experienced by the subject in this case study can be prevented by further improvement in the dental procedures used to remove and replace amalgams. However, unless one is aware of the potential side effects and makes a special effort, it is difficult to protect the surrounding soft tissue from exposure to the strong bluish curing light, since the beam coming from the end of the round bundle of optic fibers also splays conically outward beyond the diameter of the bundle (see Figure 6). A protective covering, either at the end of the bundle of optic fibers where the light is emitted or directly on the soft tissue surrounding the tooth being treated should be used. Another factor to be considered for protecting the soft tissues surrounding the treated teeth is the relationship between the wavelengths of the bluish curing light and the possible contribution of the intensive bluish curing light to the genesis of pre-cancer or cancer. If this light contains ultraviolet spectra, it is clearly hazardous since repeated exposure to strong ultraviolet light is well known as a potential cause of cancer. But, if the curing beam does not contain ultraviolet light, then the question is whether or not this range of wavelengths of 400-520 nm is in itself, also, a contributing factor to carcinogenesis. If one presumes the curing lightbeam does not contain a wavelength in the ultraviolet spectra, then a third possibility for the genesis of pre-cancer in this clinical case, could be the combination of a unique biochemical condition of the patient's oral tissue as the result of Hg deposition and exposure to the strong curing light which is supposedly safe.

This study, as well as our previous studies on non-invasive removal of metals from the body, shows that mercury deposits resulting from the removal of dental amalgam fillings or other sources, such as radioisotope Thallium 201 injection for cardiac SPECT, can be successfully removed by taking Chinese parsley orally (as a safe and effective chelating agent), with drag uptake enhancement methods, which can even be initiated before removal of the dental amalgams ( 2, 4, 19). Ideally, at least one day before the removal of the dental amalgam by drilling, Chinese parsley combined with drug uptake enhancement should be initiated so that the pre-existing mercury from the amalgam can first be eliminated or reduced. After the removal of the dental amalgam, the treatment should be continued for a minimum of two weeks. If drug uptake enhancement is not combined, and only Chinese parsley or another alternative chelating agent is taken alone, treatment may take much longer. Use of intensive bluish curing light beams in the dental procedure can lead to the inadvertent exposure of the tongue and gingiva which may induce unexpected pre-cancer in the exposed tissue of the oral cavity as well as in the corresponding organs represented by the areas of the tongue which are exposed to the intensive curing light beams. The pre-cancer condition may be treated effectively with a combination of anti-viral agents such as EPA with DHA, and Chinese parsley and drug uptake enhancement methods. Potential iatrogenic medical problems associated with removal of dental amalgam fillings, and inadvertent exposure of the gingiva and the side of the tongue adjacent to the involved teeth to strong bluish curing light can be reversed by the effective medical treatment described in this study. However, further study is necessary to clarify many of the questions which are raised by this very limited and preliminary single case clinical study.
(This research is supported by the Heart Disease Research Foundation.)

References:

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(23.) Omura, Y., Basic Electrical Parameters for Safe and Effective Electro-Therapeutics (Electro-Acupuncture, TENS, Electro-Magnetic Field Stimulation) and Comparison between Low Pulse Repetition Rate and High Pulse Repetition Rate Stimulation for Circulation & Drug Uptake Enhancement Effects. Acupuncture & Electro-Therapeutics Research, The International Journal., Vol. 19, No. 3 & 4, p. 248, 1993.

(24.) Omura, Y. & Ishida, Y., Search for the Mechanism of Bio-Sensor: When Given Medication is Ineffective what do You Suspect? How do you Identify Whether Drug is Reaching the Pathological Area to be Treated? How do You Judge the Drug-Drug Interaction? Listen to the Originator of the Bi-Digital O-Ring Test, Yoshiaki Omura. Sawarabi. (Japanese Quarterly Medical Journal Published by Medical Review Publishing Co., Osaka, Japan) No. 18, pp. 30-36, April 1, 1994.
(25.) Omura, Y., Beckman, S.L., Application of Intensified (+) Qi-Gong Energy, (-) Electrical Field, (S) Magnetic Field, Electrical Pulses (1-2 Pulses/sec), Strong Shiatsu Massage of Acupuncture on the Accurate Organ Representation Areas of the Hands to Improve Circulation and Enhance Drug Uptake in Pathological Organs: Clinical Applications with Special Emphasis on the "Chlamydia-(Lyme)-Uric Acid Syndrome" and "Chlamydia-(Cytomegalovirus)-Uric Acid Syndrome." Acupuncture & Electro-Therapuetics Research, The International Journal. Vol. 20, No. 1, pp.21-72, 1995.
(26.) Omura, Y., Effective Treatment of Intractable Medical Problems Using Accurate Organ Representation Areas of the Hand or the Cardiovascular Representations Area of the Medulla Oblongata Beneath the Occipital Area of the Skull with Drug Uptake Enhancement Methods Including Acupuncture, (+) Qi Gong, Shiatsu Massage, South Pole Magnetic Field, (-) Electrical Field and Others. Abstracts of the ICMART Symposium and 2nd Bulgarian Acupuncture Congress, p.1, held at the Hotel Vitosha, Sophia, Bulgaria, June 1-5, 1995.

(27.) Omura, Y. A New, Simple, Non-Invasive Imaging Technique of Internal Organs and Various Cancer Tissues Using Extended Principles of the "Bi-Digital O-Ring Test" Without Using Expensive Imaging Instruments or Exposing the Patient to Any Undesirable Radiation. Acupuncture & Electrotherapeutics, The International J. Vol. 10:255-277, 1985.
(28.) Omura, Y. "Bi-Digital O-Ring Test Molecular Identification and Localization Method" and its Application in Imaging of Internal Organs and Malignant Tumors as Well as Identification and Localization of Neurotransmitters and Microorganisms -- Pan I. Acupuncture & Electro-Therapeutics Research. International J. Vol. 11: 65-100, 1986.
(29.) Shimostuura, Y., Saito, Y., Nakano, M., Muteki, G. Simple and quick gastric cancer screening method using the "Bi-Digital O-Ring Test" and its critical evaluation by standard X-ray, gastroscopic and pathological microscopic examination. Acupuncture & Electro-Therapeutics Research, International J. Vol. 12: 193-200, 1987.

(30.) Omura, Y., Simple non-invasive early detection and localization of specific cancer tissues of internal organs and differentiation of cancer tissue from surrounding areas infected by cancer related viruses, as well as evaluation of their micro-circulatory condition & drug uptake using the Bi-Digital O-Ring Test, Acupuncture & Electro-Therapeutics Research, The International Journal., Vol 15: No. 3 & 4, PP. 217-233, 1990.

(31.) Omura, Y., Losco, M., Omura, A., Takeshige, C., Hisamitsu, T., Nakajima, H., Soejima, K., Yamamoto, S., Ishikawa, H., Kagoshima, T., Watari, N., Shimosuura, Y., Matsubara, T. Bi-Directional Transmission of Molecular Information by Photon or Electron Beams Passing in the Close Vicinity of Specific Molecules, and its Clinical and Basic Research Applications: 1) Diagnosis of Humans or Animal Patients Without Any Direct Contact; 2) Light Microscopic and Electron Microscopic Localization of Neuro-transmitters, Heavy Metals, Oncogen C-fos (Ab2), etc. of Intracellular Fine Structures of Normal and Abnormal Single Cells Using Light or Electron-Microscopic Indirect Bi-Digital O-Ring Test. Acupuncture & Electro-Therapeutics Research, International J. Vol. 17: 29-46, 1992.

(32.) Omura, Y., Losco, Bro. M., Electro-magnetic fields in the home environment (color TV, computer monitor, microwave oven, cellular phone, etc.) as potential contributing factors for the induction of Oncogen C-fos Abl, Oncogen C-los Ab2, Integrin à(5)á(1) and development of cancer, as well as effects of microwave on amino acid composition of food and living human brain. Acupuncture & Electro-Therapeutics Research. The International Journal., Vol. 18, No. 1, pp. 33-73, 1993.

(33.) Omura, Y., Simple non-invasive early detection and localization of specific cancer tissues of internal organs and differentiation of cancer tissue from surrounding areas infected by cancer related viruses, as well as evaluation of their micro-circulatory condition & drug uptake using Bi-Digital O-Ring Test. Program & Abstracts of 1st International Symposium on the Bi-Digital O-Ring Test organized by the Japan Bi-Digital O-Ring Test Assoc. and held at Waseda University, International Conference Center, Tokyo, Japan, pp. 63-64, May 7-9, 1993.

(34.) Omura, Y., Application of The Bi-Digital O-Ring Test for Diagnosis and Effective Treatment of Intractable Pain, Infection, & Cancer Using Selective Drug-Uptake Enhancement Methods, and the Relationship Between These Intractable Problems and Harmful Environmental Electro-Magnetic Fields & Localized Heavy Metal Deposits in the Body., Abstracts of The 6th Congress of Japan Bi-Digital O-Ring Test Medical Society., pp 58-61 August 8-10, 1996.
(35.) Omura, Y., Accurate localization of organ representation areas of the tongue, using the Bi-Digital O-Ring Test: Its clinical application, and re-evaluation of classical oriental tongue diagnosis -- Part I, Acupuncture & Electro-Therapeutics Research, The International Journal., Vol 16: No. 1 & 2, pp. 27-43, 1991.

(36.) Omura, Y., Losco, M., Takeshige, C.,Shimotsuura, Y., Localization & Clinical Applications of Organ Representation Areas (at the Cerebral Cortex, Tongue, Etc.), & Mapping of Meridians & Acupuncture Points. Abstract, Third World Congress of the World Federation of Acupuncture, Kyoto, Japan, 1993.

(37.) Omura, Y., Microbial infection or trauma at cardiovascular representation area of medulla oblongata as some of the possible causes of hypertension or hypotension, Acupuncture & Electro-Therapeutics Research, The International Journal., Vol. 13: pp. 131-145, 1988.

(38.) Omura, Y., Acupuncture Medicine: It's Historical and Clinical Background, Japan Publications, Inc., Tokyo, Japan, 1982. 2nd. edition. Cognizant Communications Corporation, New York, 1996.

(39.) Omura, Y., Accurate Localization of Organ Representation Areas on the Feet & Hands Using the Bi-Digital O-Ring Test Resonance Phenomenon: Its Clinical Implication in Diagnosis & Treatment -- Part I. Acupuncture and Electro-Therapeutics Research: The International Journal. Vol. 19, Nos. 2 & 3, pp. 153-190, 1994.

(40.) Omura, Y., Losco, Bro. M., Omura, A.K., Yamamoto, S., Ishikawa, H., Takeshige, C., Watari, N., Nakajima, H., Matsubara, T., Bi-Directional transmission of molecular information by photons or electron beams passing in the close vicinity of specific molecules, and its clinical and basic research applications: 1) Diagnosis of humans or animal patients without any direct contact; 2) light microscopic and electron microscopic localization of neuro-transmitters, heavy metals, oncogen C-fos (Ab2), etc. of intracellular fine structures of normal and abnormal single cells using light or electron-microscopic indirect Bi-Digital O-Ring Test, Acupuncture & Electro-Therapeutics Research, The International Journal., Vol 17: No.1, pp. 29-46, 1992.

(41.) Omura, Y., Losco, Bro. M., Omura, A.K., Takeshige, C., Hisamitsu, T., Shimotsuura, Y., Yamamoto, S., Ishikawa, H., Muteki, T., Nakajima, H., Urich, C., Common factors contributing to intractable pain and medical problems with insufficient drag uptake in areas to be treated, and their pathogenesis and treatment: Part I. Combined use of medication with acupuncture, (+) Qi Gong energy-stored material, soft laser or electrical stimulation, Acupuncture & Electro-Therapeutics Research, The International Journal., Vol 17: No.2, pp. 107-148, 1992.
(42.) Omura, Y., Losco, Bro. M., Electro-magnetic fields in the home environment (color TV, computer monitor, microwave oven, cellular phone, etc.) as potential contributing factors for the induction of Oncogen C-fos Ab1, Oncogen C-fos Ab2, Integrin à(5)á(1) and development of cancer, as well as effects of microwave on amino acid composition of food and living human brain. Acupuncture & Electro-Therapeutics Research, The International Journal., Vol. 18, No. 1, pp. 33-73, 1993.

(43.) Omura, Y., Losco, M., Takeshige, C., Non-Invasive Evaluation of the Effects of Opening & Closing of Eyes, and of Exposure to a Minute Light Beam, as well as to Electrical or Magnetic Field on the Melatonin, Serotonin, & other Neuro-Transmitters of Human Pineal Gland Representation Areas & the Heart. Acupuncture & Electro-Therapeutics Research, The International Journal., Vol. 18, No. 2, pp. 125 - 151, 1993.

(44.) Shintani, S., Yoshihama, Y., Emilio, A.R., Matsumura, T., Overexpression of p53 is an Early Event in the Tumorigenesis of Oral Squamous Cell Carcinomas. Anticancer Research, Vol. 15, No. 2, pp. 305 - 308, 1995.
(45.) Emilion, G., Langdon, J.D., Speight, P., Partridge, M., Frequent Gene Deletions in Potentially Malignant Oral Lesions. British Journal of Cancer., Vol. 73, No. 6, pp.809 813, 1996.

(46.) Peters, E., McGaw, W.T., Detection of Premalignant Oral Lesions: A 10 Year Retrospective Study in Alberta, Journal of the Canadian Dental Association., Vol. 61, No. 9, pp. 775 - 778, 1995.
47. Lumerman, H., Freedman, P., and Kerpel, S., Oral Epithelial Dysplasia and the Development of Invasive Squamous Cell Carcinoma. Oral Surgery, Oral Medicine, Oral Patholo

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