Progesterone questions



QUESTION: What is the difference between natural and synthetic progesterone?

ANSWER: Progesterone was first crystallized in 1934, and today is available from plant sources. Natural micronized progesterone is an exact chemical duplicate of the progesterone that is normally produced by the ovary. Synthetic progesterone, called progestogen, mimics the action of the progesterone, but the body does not respond in the same way. Studies have shown that progestogen actually reduces the level of progesterone in the blood stream.

QUESTION: Are there side effects with natural progesterone?

ANSWER: Natural progesterone combines with progesterone receptor sites, and elicits biological effects without many of the undesirable side effects that are seen with the synthetic forms. Perhaps the only disadvantage to natural progesterone is that it is short-acting and to maintain adequate blood levels it has to be dosed four times daily. A small number of women may experience transient lightheadedness or drowsiness.

QUESTION: How does oral natural progesterone work?

ANSWER: The oral route of progesterone administration has long been considered impractical because of poor absorption and short biological half life. Contrary to traditional teachings, recent reports confirm that significant serum progesterone levels can be achieved with new modification in the preparation of progesterone for oral administration including micronization and dissolution in oils consisting of principally long chain fatty acids.

QUESTION: Is the oral form of natural progesterone approved by the FDA?

ANSWER: Natural micronized progesterone has F.D.A. approval. The oral form of natural progesterone is compounded from a physician's prescription by a licensed pharmacist using F.D.A. approved ingredients. Therefore, it does not require separate F.D.A. approval.

QUESTION: Isn't it true that natural progesterone taken orally is destroyed by stomach acid? How does the oral progesterone you compound achieve adequate blood levels ?

ANSWER: Natural progesterone in powder form is destroyed by stomach acid. But, when compounded in an oil base, the progesterone is so firmly held by the oil base that it is actually absorbed through the lymphatic system first, thereby allowing a couple of passes through the body before being cleared via the liver.

Testosterone--5 mg
Testosterone--64 mg (can be taken every other day for male
menopause, or male andropause)

Progesterone--100 mg
Progesterone--50 mg/Testosterone--2.5 mg
Progesterone--.5 mg/Estradiol--100 mg

Estradiol--.5 mg
Estradiol--.25 mg
Estradiol--.5 mg/Testosterone .5 mg

Women who are menopausal should use the 5 mg of testosterone as therapy. Women with PMS should use pure progesterone/testosterone combination. Hormone levels can be measured by blood tests.


By Rabbi Eric Braverman, M.D.

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