Quantum Medicine Update: Novel Detoxification Methods to Counteract Global Pollution

Quantum Medicine Update: Novel Detoxification Methods to Counteract Global Pollution

In their countless guises xenobiotics perform amazing feats of chemistry as they mimic and block hormones, inhibit enzyme activity, and compromise detoxification systems by depleting nutrients needed to support Phase I and Phase II liver detoxification. Now biochemists have uncovered new information in their repertoire. Early attempts to upregulate liver detoxification were not clinically successful. Biochemists have since learnt that xenobiotics trigger a complex set of maneuvers that reshuffle the genetic code and disrupt proteins needed for the proper biliary conjugation and excretion of heavy metals.

Reshuffling the genetic code can result in altered genetic expression that triggers oxidative stress, hormone resistance, and inflammation. Although the complete mechanism isn't understood, my clinical research has uncovered the critical importance of balancing Phase I and Phase II liver detoxification, supporting the biosynthesis of bile acids and trans sulfuration-sulfate pathways to encourage the excretion of xenobiotics through the liver's bile ducts while enhancing the production of glycoproteins.

The body's elegant detoxification mechanisms need a constant supply of nutrients to remove waste products and xenobiotics through basement membrane ultrafilters (ground regulation system). Maintaining responsive biocommunication from peripheral tissues and organs to central control and feedback systems via the ground regulation system (GRS) is critical in any detoxification protocol (Townsend Letter for Doctors & Patients, January 1999 and April, 1999).

Most detoxification protocols I have examined deplete the cell of GSH, inhibit antioxidant processes and cause neurotoxic and nephrotoxic reactions. For example, L-cysteine or N-acetylcysteine supplementation -- without the use of other conjugating agents, co-factors and precursors in the proper ratios -- in a metal-burdened patient can disturb GRS regulation and facilitate redistribution of metals from tissues throughout the body into the brain, leading to neurodegenerative disorders like Parkinson's, Alzheimer's, and MS.

When the body's GRS is not able to discharge metals efficiently, physiological systems operate without resilient reserves and repair mechanisms are inhibited. Repair is no longer prompt, efficient, or complete and the immune system shifts from tolerance to amplified inflammatory overactivity (allergic and multiple chemical sensitivity syndromes). When the body's GRS is compromised by metabolic poisons, chronic fatigue, fibromyalgia, Syndrome X, and mitochondrial dysfunction can emerge. With the Targeted Response Detoxification Method (TRDM(*)) -- introduced in my April 1999 Quantum Medicine Update column -- I have observed restoration of GRS regulation and neurohormonal energetics in many patients with treatment-resistant disorders.

Long-term Retrospective Study of TRDM

No single etiological factor of effective xenobiotic detoxification exists. Human undernutriture is most commonly a composite of multiple deficiencies of variable extent, modulated further by digestive dysfunction and environmental factors. Therefore, this study utilized precise ratios of metabolically active nutrients -- functioning as co-factors and precursors -- in Phase I and II liver detoxification pathways: vitamin C (calcium ascorbate), quercitin (dehydrate), selenium aspartate, Betaine, vitamin B6 (P-5-P), vitamin B2 (R-5-P), vitamin B1 (TTP), Folic acid, vitamin B12, L- Cysteine (HCL), L-Taurine, L-Methionine, Glycine, Serine, Glutathione (reduced), Inosine, CoenzymeQ10, N Acetyl Cysteine, Pine Bark Extract, Lipoic acid, Manganese (Glycinate), Zinc (Picolinate), Copper (Lysinate), Turmeric, Icelandic Sea Produce (acophyllum nodosum), Rosemary (extract), and homeopathic combinations to activate GRS detoxification.

Methods: Forty patients, suffering with multisystem disorders (Fibromyalgia, Chronic Fatigue Syndrome, Syndrome X, Leaky Gut Syndrome, and digestive and neurodegenerative disorders) were randomly chosen from our clinic to study the influence of co-factor and precursor nutrients on nine basic categories: energy levels, mental function, skin, immune function, digestive function, body composition, urinary function, sexual function, and body composition.

Assessment of these patients included the following:

anthropometric data dealing with height, weight, blood pressure, neuromuscular assessment, physician examination,(**) and a segmentelectrogram to assess total body regulation,
dietary and lifestyle assessment,
family and medical/personal health history,
patient symptom evaluation with organ-system emphasis before and after therapy,
functional assessment (electrodermal biofeedback) before and after therapy
It is interesting to note that thirty-three patients had symptoms for a period of three or more years. Eight patients had pretreatment symptoms for a period of six months to two years. All these patients had a history of unsuccessful medical treatment with two or more medical physicians. The duration of treatment varied with each patient with the average treatment time being three to six months to improve long-term deficiency states and upregulate detoxification mechanisms.

Pre- and post-treatment evaluations were determined by each patient's assessment of the following categories: fatigue, mental symptoms, skin, immune, digestive function, urinary tract symptoms, and sexual function. This retrospective study described the use of the TRDM(*) along with dietary management in 40 patients with treatment aimed at reducing signs of nutritional inadequacy and improving general health and well being. The study attempted to answer the following questions: 1. What is effect of using co-factor/precursor nutrients and a healthy diet on the signs and symptoms of nutritional inadequacy and xenobiotic toxicity? 2. What is the effect of improving gut function on these patients? 3. What clinical conclusions can one draw from these data?

Results: Question One: Each patient's own rating of each of their categories: "worse, no change, slight, moderate, or totally improved" in each category were as follows: all 40 patients reported slight to total improvement in their energy levels despite the fact that 70% of these individuals were diagnosed with Chronic Fatigue Syndrome (CFS, CFIDS), Fibromylagia, Syndrome X, allergies and Multiple Chemical Sensitivity Syndrome -- conditions that were not improved with previous medical management. In addition, significant improvements in mental, immune, digestive, urinary, and sexual function were also reported in the majority of patients. Body composition improved in all but five individuals. Hence, in answer to the first question, one could conclude that the TRDM and a healthier diet (more fresh fruits, vegetables, whole grains and seeds and less animal protein and animal fats) can reduce the signs and symptoms of nutritional inadequacy and xenobiotic toxicity in the majority of patients without increasing neurotoxicity or neprotoxicity as I have observed in the past with other detoxification methods.

Question Two: Thirty-six patients reported moderate or complete improvements in digestive function. Sixty percent of these patients were diagnosed with duodenitis or gastritis, 80% were diagnosed with Irritable Bowel Syndrome, 70% had long-term constipation and/or dysbiosis. Increased nutrient uptake was evident in these cases. Hence, in answer to the second question, gut function can be improved in the majority of individuals with diet and nutrition designed to upregulate GRS/liver detoxification mechanisms.

Question Three: Does the data in this study guarantee individuals a longer, healthier life? Obviously, this clinical data needs more comprehensive biochemical studies to document the predictive effects of cofactor/precursor nutrition and diet on health and longevity. However, it is plausible that the majority of individuals who improve their detoxification abilities can live a healthier life. Based on the continued management of these patients, it is highly probable that the TRDM can prevent the incidence of age-associated diseases that result in sub-optimal function of mental function, immune function, digestive function, urinary function, and sexual function with advancing age. By attempting to maximize the biochemical strengths and minimize weaknesses in our patients and being alert to early warning signs of nutritional inadequacy -- documented in hundreds of scientific and clinical studies -- we can reduce or eliminate altered genetic expression, oxidative stress, and inflammation. All of the answers and proof of the efficacy of using nutrition to detoxify xenobiotics are not available at this time. But the data at this point is strong enough to suggest that diet and nutrition can minimize risks and improve the potential for a longer, healthier life in the American population.

The validity of this empirical data is strengthened by hundreds of scientific papers that document the effects of specific nutrients on modulating detoxification and anti-inflammatory bioactivity and the fact that these nutrients also function as precursors and cofactors in the biochemical pathways of steroidal, peptide, and ecosanoid hormones. The primary goal of TRDM(TM)(*) is to prevent xenobiotics from interfering with the synthesis, storage/release, transport, metabolism, binding, action or elimination of natural blood-borne hormones that are responsible for the regulation of a myriad of metabolic processes. Already studies are connecting xenobiotics with impaired thyroid function and permanent alterations in brain function in adulthood (Toxicol & Appl Pharm, 135, 77-88) and in children (Amer J Pub Health 77, 1294-97). Researchers have reported disrupted liver detoxification in Parkinson's and Alzheimer's disease patients as compared to controls (Neuroscience Letters, 110:216-20, 1990; Toxicol. 111:43-65,1996).

There is a striking commonality of symptoms and an overlap among many of the syndromes we are faced with on a daily basis in clinical practice. Neurologic, allergic, genitourinary, fatigue, and chemical sensitivity symptoms can be exacerbated by detoxification protocols that fail to minimize the transport of metals into the GRS, CNS and glands of the body. Indeed, autopsies have reported high levels of Hg in cardiac, thyroid, pituitary, and brain tissues of dentists (Swed Dent J, 11:179-87, 1987). Clearly, a poor metabolic reserve in sulfur metabolism pathways is common in many treatment-resistant syndromes along with a depletion or poor assimilation of nutrient co-factors and precursors.

Summary

With reports on climate change, ozone depletion, wildlife extinction, deforestation, it's increasingly clear that we are paying for global damage in a precious currency: our health. These worldwide threats are so big and so widespread that it's impossible for them not to hit us where it hurts. In fact, they're already having an impact on health by depleting nutrient reserves that control detoxification. Global changes are causing an alarming increase in allergic and infectious diseases -- opening the way for new powerful diseases.

At the Global Warming Summit in 1998, the World Wide Fund for Nature warned that the world faces the prospect of "an explosive spread in infectious diseases that are already claiming new victims in industrialized countries." The world is facing a global warming of between 1.5 and 4.5 centigrade in the next century due to 20 billion tons of carbon dioxide being pumped into the atmosphere every year.

Dire as such a future seems, the fact that people can do something positive to protect their health from these environmental threats, merits attention. Rapid and turbulent global changes are threatening our survival. To meet this challenge, the TRDM(*) offers effective solutions to the insidious threat of pollutants that interfere with our ability to reproduce and function sexually and slow down the body's natural ability to repair and heal itself.

Between discovery and application, between invention and clinical application, there is a world of innovation, of clinical improvements that can be made in current detoxification protocols. Innovations and incentives to develop new, viable, detoxification processes have led to the creation of TRDM(TM)(*). Effective outcome disease management in treatment-resistant syndromes should support the sulfation of steroids, lipids, peptides, neurotransmitters, thyroid hormones that are diminished with xenobiotic toxicity (Molecular Pharmacol 41:645-51,1992) while providing targeted control Phase I and II liver detoxification pathways. This approach attempts to minimize xenobiotic-induced molecular terrorism by normalizing redox and restoring neuroendocrine regulation (Human Exp Toxicol 1:547-55, 1996). In retrospect, the TRDM(TM) may rank as the safest, most advanced detoxification approach ever developed. Early detection of xenobiotic toxicity and appropriate treatment is important for successful detoxification.

(*)TRDM is available through Bioactive Nutritionals, Melbourne, Florida who also manufactures and sells the homeopathic formulations utilized in the author's clinical research. The statements made regarding the products described in this article have not been evaluated by the Food and Drug Administration. These products are not intended to treat, cure, or prevent disease.

(**)Physician examinations performed by Marcellus Walker, MD The author gratefully acknowledges his assistance in this study.

Note: All the above research was done on the author's own time without compensation from any funding source or private/professional corporation. The author is not employed, nor is a consultant of any nutritional company. However, as the formulator of the TRDM product, the author acknowledges receiving a royalty on the sales of this product.

Article copyright Townsend Letter for Doctors & Patients.

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By Paul Yanick

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