Vitamin E and Alzheimer disease

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Studies from throughout the world that can help you live longer

Evidence suggests that oxidative stress is important in the pathogenesis of Alzheimer disease. In particular, beta-amyloid, which is found abundantly in the brains of those with Alzheimer disease, is toxic in neuronal cell cultures through a mechanism involving free radicals. Vitamin E prevents the oxidative damage induced by beta-amyloid in cell culture and delays memory deficits in animals. A study of 2000 IU/day of vitamin E was conducted in those with moderately advanced Alzheimer disease. The results indicated that vitamin E may slow functional deterioration leading to nursing home placement. A new clinical trial is planned that will examine whether vitamin E can delay or prevent a clinical diagnosis of Alzheimer disease in elderly persons with mild cognitive impairment.

AMERICAN JOURNAL OF CLINICAL NUTRITION, 2000, Vol 71, Iss 2, pp 630S-636S

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