Clinical research Treatment of Osteoporosis with a traditional formula that supplements the kidney

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Objective:
To investigate the effect mechanisms in treatment of osteoporosis.

After analyzing various Chinese medical literatures, the principles of supplementing the kidneys and enriching yin were chosen as the principle of the kidney yin vacuity type of osteoporosis. In order to ascertain the validity and clinical significance of the princple, a traditional formula called Liu Wei Di Haung Wan, based on these metods, was used to treat women suffering from postmenopausal osteoporosis (PMOP).

Method:
100 women with outpatient PMOP were selected and divided into two groups according to single blind randomized control method, 70 cases in the Liu Wei Di Haung Wan group and 30 cases in a control group given calcium supplement. None of the subjects had received any medicaitons that treat or affect osteoporosis 6 months prior to the study.

The efficacy of treatment was evaluated by analyzing and comparing the bone material content (BMC) and bone mineral density (BMD) of the sacral spine 2-4 and femoral neck of the two groups, as well as kidney yin vacuity symptoms scores prior to and after treatment. The levels of E2, IL-6 and BGP were also measured six months prior to and after treatment using fasting blood and urine samples.

Conclusion:
The formula Liu Wei Di Haung Wan supplements the kidneys and enriched yin. It is comprised of Shu Di Haung (Rehmannia glutinosa Libosch), Shan Yao (Dioscorea alata L. var. purpurea.), Shan zhu yu (Cornus florida L.), Lu Lin (Smilax glabra.), Ze Xei (Smilax glabra.) and Dan Pi (Paeonia suffruticosa Andr.). Through clinical observation and controlled experiments, Liu Wei Di Haung Wan has been proved to have a twofold effect on bone growth. Liu Wei Di Haung Wan can increase BMC and BMD while reducing bone turnover, thus strengthening bones. Liu Wei Di Haung Wan also improves kidney yin vacuity symptoms and relieves pain caused by POMP, including lumbar pain, back pain as well as muscular pain.

Based on summation of evidence from clinical observation, treatment of kidney yin vacuity type of osteoporosis with Chinese formula should follow the principle of supplementing the kidney and enriching yin.

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By Tseng Chuen Chang

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