Yohimbine--Effective for Erectile Dysfunction

Yohimbine -- Effective for Erectile Dysfunction

Reference: Ernst E, Pittler MH. Yohimbine for erectile dysfunction: A systematic review and meta-analysis of randomized clinical trials. J Urol 1998; 159:433-6.

Summary: This study reviews seven methodologically rigorous controlled trials on the use of yohimbine for treatment of impotent patients. An attempt to find unpublished positive or negative trials uncovered no evidence that such trials existed. Meta-analysis clearly showed yohimbine was superior to placebo for organic, psychogenic and mixed impotence. The typical dose used in these studies of yohimbine hydrochloride was 6 mg three times daily, though some trials went as high as 12 mg four times daily. Younger patients seemed to respond better. No serious adverse effects were reported in any study, and only eight patients (out of hundreds of patients studied) dropped out because of negative results. The most common minor side effects were allergic rash or gastrointestinal upset, hypertension, anxiety, headache, and increased urinary frequency. In most studies the incidence of minor adverse effects was not significantly different from those seen in placebo groups. The authors conclude yohimbine is a safe, effective, and low-cost option for treatment of all types of impotence.

Natural Product Research Consultants, Inc.

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By E. Yarnell

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